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| Nomenclature |
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Symbol:
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Abl1tm1Mlg
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Name:
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c-abl oncogene 1, non-receptor tyrosine kinase;
targeted mutation 1, Richard C Mulligan
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MGI ID: |
MGI:2153718 |
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Synonyms: |
abl-, Abl2, ablm2, c-Abl-, c-abl2 |
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Gene:
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Abl1
Location:
Chr2:31688376-31804227 bp, + strand
Genetic Position: Chr2,
21.86 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72875
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exon 5 and part of exon 6 was replaced by a neomycin resistance cassette. These sequences encode the N-terminal part of the tyrosine kinase domain, including the nucleotide and ATP binding sites. (J:72875)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:72875
Tybulewicz VL et al.,
"Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene."
Cell 1991 Jun 28;65(7):1153-63
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All: |
27 reference(s)
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Analysis Tools
