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| Nomenclature |
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Symbol:
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Sparcl1tm1Pmc
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Name:
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SPARC-like 1;
targeted mutation 1, Peter J McKinnon
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MGI ID: |
MGI:2153047 |
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Synonyms: |
hevin null |
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Gene:
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Sparcl1
Location:
Chr5:104079111-104114088 bp, - strand
Genetic Position: Chr5,
50.55 cM, cytoband E4
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Abnormal Purkinje cell morphology in the Sparcl1tm1Pmc/Sparcl1tm1Pmc and Adamts4tm1Dqp/Adamts4tm1Dqp cerebellum
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59207
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced exon 2, which encodes the secretion signal sequence. RNAse protection assays demonstrated an absence of transcript in RNA derived from cerebellum of adult homozygous mice. Western blot and immunohistochemical analysis did not detect the protein in brain of homozygous mice. (J:59207)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sparcl1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:59207
McKinnon PJ et al.,
"Extracellular matrix-associated protein Sc1 is not essential for mouse development."
Mol Cell Biol 2000 Jan;20(2):656-60
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All: |
6 reference(s)
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Analysis Tools
