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| Nomenclature |
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Symbol:
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Vwftm1Wgr
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Name:
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Von Willebrand factor homolog;
targeted mutation 1, Denisa D Wagner
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MGI ID: |
MGI:2153009 |
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Synonyms: |
vWf-, VWF KO |
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Gene:
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Vwf
Location:
Chr6:125546774-125686679 bp, + strand
Genetic Position: Chr6,
59.32 cM
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Spontaneous bleeding events in Vwftm1Wgr/Vwftm1Wgr mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49083
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into intron 5. Northern blot analysis revealed that no normal transcripts were present in homozygous mice, and immunofluorescence experiments demonstrated that the protein was not present in blood smears of homozygous mice. (J:49083)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:49083
Denis C et al.,
"A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis."
Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9524-9
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All: |
45 reference(s)
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Analysis Tools
