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| Nomenclature |
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Symbol:
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Col2a1tm1Prc
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Name:
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collagen, type II, alpha 1;
targeted mutation 1, Darwin J Prockop
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MGI ID: |
MGI:2152978 |
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Gene:
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Col2a1
Location:
Chr15:97975602-98004695 bp, - strand
Genetic Position: Chr15,
53.97 cM
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Abnormal intervertebral disc development in Col2a1tm1Prc/Col2a1tm1Prc mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30041
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 35. RT-PCR analysis demonstrated the presence of a transcript that terminated at exon 35. A mature protein was not detected in cultured cartilage cells isolated from homozygous mice. (J:30041)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Col2a1 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:30041
Li SW et al.,
"Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone."
Genes Dev 1995 Nov 15;9(22):2821-30
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All: |
8 reference(s)
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Analysis Tools
