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| Nomenclature |
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Symbol:
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Col9a1tm1Jae
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Name:
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collagen, type IX, alpha 1;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:2152964 |
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Gene:
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Col9a1
Location:
Chr1:24177610-24252684 bp, + strand
Genetic Position: Chr1,
9.95 cM
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Histology of knee joint articular cartilage of wild-type control and Col9a1tm1Jae/Col9a1tm1Jae mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:18628
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 8 in reverse transcriptional orientation relative to the gene. Northern blot analysis on RNA derived from E17.5 homozygous embryos demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts of rib cage and vertebral column from homozygous mice confirmed that no stable encoded protein was present. (J:18628)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:18628
Fassler R et al.,
"Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease."
Proc Natl Acad Sci U S A 1994 May 24;91(11):5070-4
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All: |
14 reference(s)
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Analysis Tools
