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| Nomenclature |
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Symbol:
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Pdx1tm1Ted
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Name:
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pancreatic and duodenal homeobox 1;
targeted mutation 1, Thomas Edlund
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MGI ID: |
MGI:2152755 |
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Synonyms: |
Ipf1-, pdx1- |
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Gene:
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Pdx1
Location:
Chr5:147269959-147278008 bp, + strand
Genetic Position: Chr5,
86.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:20779
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced exon 2, deleting sequences that encode the homeodomain, the splice acceptor site, and flanking intron sequences. Whole-mount immunohistochemical studies did not detect protein in homozygous mutant embryos.
(J:20779)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pdx1 Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:20779
Jonsson J et al.,
"Insulin-promoter-factor 1 is required for pancreas development in mice."
Nature 1994 Oct 13;371(6498):606-9
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All: |
15 reference(s)
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Analysis Tools
