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| Nomenclature |
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Symbol:
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Gnastm1Gwa
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Name:
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GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus;
targeted mutation 1, Gary Wand
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MGI ID: |
MGI:2152744 |
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Synonyms: |
GnasE1- |
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Gene:
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Gnas
Location:
Chr2:174284320-174346744 bp, + strand
Genetic Position: Chr2,
97.89 cM, cytoband E1-H3
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Subcutaneous ossifications in Gnastm1Gwa/Gnas+ mice
Show the 6 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70175
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 0.5kb of sequence containing the ATG codon and extending through an NruI site in intron 1. Quantitative immunoblot studies showed protein levels in multiple brain regions of mice heterozygous for this allele were significantly reduced relative to wild-type.
(J:70175)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gnas Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:70175
Wand G et al.,
"The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol."
J Neurosci 2001 Jul 15;21(14):5297-303
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All: |
5 reference(s)
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Analysis Tools
