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| Nomenclature |
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Symbol:
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Grb2tm1Paw
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Name:
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growth factor receptor bound protein 2;
targeted mutation 1, Tony Pawson
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MGI ID: |
MGI:2152451 |
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Synonyms: |
deltaGrb2, Grb2- |
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Gene:
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Grb2
Location:
Chr11:115644045-115708597 bp, - strand
Genetic Position: Chr11,
80.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51424
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exons 2 and 3 was replaced with a vector containing a neomycin selection cassette by homologous recombination. Immunoprecipitation and western blotting experiments on cell lysates derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:51424)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51424
Cheng AM et al.,
"Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation."
Cell 1998 Dec 11;95(6):793-803
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All: |
12 reference(s)
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Analysis Tools
