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| Nomenclature |
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Symbol:
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Apoetm1Lmh
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Name:
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apolipoprotein E;
targeted mutation 1, Louis M Havekes
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MGI ID: |
MGI:2152302 |
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Synonyms: |
apoe-, Apoe0 |
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Gene:
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Apoe
Location:
Chr7:19696109-19699166 bp, - strand
Genetic Position: Chr7,
9.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:22347
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A hygromycin B resistance cassette replaced exons 1, 2, and part of 3 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable transcript. Western blots from homozygous mutant mice showed no detectable protein. (J:22347)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apoe Mutation:
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54 strains or lines available |
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| References |
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Original: |
J:22347
van Ree JH et al.,
"Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice."
Atherosclerosis 1994 Nov;111(1):25-37
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All: |
37 reference(s)
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Analysis Tools
