|
|
| Nomenclature |
|
Symbol:
|
Tg(APPV717F)109Ili
|
|
Name:
|
transgene insertion 109, Ivan Lieberburg
|
|
MGI ID: |
MGI:2151935 |
|
Synonyms: |
APPInd, APPV717F, hAPP+, hbeta-APP, PDAPP, PDAPP+, PDAPP-109, PD-APP transgenic, PDAPP-V717F, PDGF-hAPP(V717F) |
|
Transgene:
|
Tg(APPV717F)109Ili
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
Not Specified
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Overexpression of a human APP (hAPP) minigene encoding the APP717V to F mutation associated with familial Alzheimer's Disease. The construct contained APP introns 6 - 8, allowing alternative splicing of exons 7 and 8. The transgene utilizes a platelet-derived growth factor promoter (PDGF-b) and the three major splicing variants of hAPP mRNA were expressed in transgenic mice. As determined by RNAse protection, line 109 expressed ~ 18-fold more APP than previously described neuron-specific enolase (NSE)-promoter-driven APP transgenes. (J:23080, J:100980)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:23080
Games D et al.,
"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein [see comments]"
Nature 1995 Feb 9;373(6514):523-7
|
|
All: |
88 reference(s)
|
|
Analysis Tools
