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| Nomenclature |
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Symbol:
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Ptentm1Rps
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Name:
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phosphatase and tensin homolog;
targeted mutation 1, Ramon Parsons
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MGI ID: |
MGI:2151804 |
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Synonyms: |
Pten- |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Histological survey of tissues in Ptentm1Rps/Pten+ mice.
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53065
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Part of exon 5 was replaced with a vector containing the neomycin resistance gene. (J:53065)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Melanoma J:155731
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| References |
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Original: |
J:53065
Podsypanina K et al.,
"Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems."
Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8
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All: |
50 reference(s)
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Analysis Tools
