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| Nomenclature |
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Symbol:
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Ppp3catm1Jse
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Name:
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protein phosphatase 3, catalytic subunit, alpha isoform;
targeted mutation 1, Jonathan G Seidman
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MGI ID: |
MGI:2150749 |
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Synonyms: |
Aalpha-, CNAa-, CnA alpha (_), CnA-alpha- |
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Gene:
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Ppp3ca
Location:
Chr3:136670124-136937727 bp, + strand
Genetic Position: Chr3,
63.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71750
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into the exon encoding nucleotides 572 - 717 of the mRNA sequence of the gene. This exon encodes part of the catalytic domain of the protein. Western blots of T cell extracts from homozygous mutant mice showed no detectable peptide. (J:71750)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ppp3ca Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:71750
Zhang BW et al.,
"T cell responses in calcineurin A alpha-deficient mice."
J Exp Med 1996 Feb 1;183(2):413-20
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All: |
16 reference(s)
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Analysis Tools
