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| Nomenclature |
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Symbol:
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Fgf8tm1.2Mrt
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Name:
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fibroblast growth factor 8;
targeted mutation 1.2, Gail R Martin
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MGI ID: |
MGI:2150346 |
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Synonyms: |
Fgf8delta2,3n |
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Gene:
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Fgf8
Location:
Chr19:45736798-45742915 bp, - strand
Genetic Position: Chr19,
38.75 cM, cytoband C3-D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45909
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is a derivative of Fgf8tm1.1Mrt in which mice carrying this allele were mated to beta-actin cre mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which exons 2 and 3 were deleted. (J:45909)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgf8 Mutation:
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4 strains or lines available |
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Notes |
One of three alleles produced using a targeting construct capable of inducing different allelic variants when mated to mice that express cre, flp, or both. Referred to in the literature as Fgf8delta2,3n, this allele lacks exons 2 and 3 and is a presumed null. Heterozygotes are normal. Homozygotes are smaller than littermates and lack all embryonic mesoderm- derived structures including heart and somites. This mutation causes lethality by embryonic day 10.5 (J:45909).
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| References |
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Original: |
J:45909
Meyers EN et al.,
"An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination."
Nat Genet 1998 Feb;18(2):136-41
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All: |
15 reference(s)
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Analysis Tools
