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| Nomenclature |
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Symbol:
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Nos3tm1Plh
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Name:
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nitric oxide synthase 3, endothelial cell;
targeted mutation 1, Paul L Huang
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MGI ID: |
MGI:2150145 |
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Synonyms: |
eNOS-, eNOS KO, NOSIII- |
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Gene:
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Nos3
Location:
Chr5:24364810-24384474 bp, + strand
Genetic Position: Chr5,
11.32 cM
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Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28778
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced 3 exons that encode the NADPH ribose and adenine binding sites of the protein (amino acids 1010 - 1144). Western blots of protein extracts of brain, heart, lung, and aorta/vena cava from homozygous mutant mice showed no detectable encoded protein. (J:28778)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice homozygous for Nos1tm1Plh
and Nos3tm1Plh
display Phenotypic Similarity to Human Syndrome: hypertensive hypertrophic cardiomyopathy of the elderly (J:129064)
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| References |
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Original: |
J:28778
Huang PL et al.,
"Hypertension in mice lacking the gene for endothelial nitric oxide synthase [see comments]"
Nature 1995 Sep 21;377(6546):239-42
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All: |
112 reference(s)
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Analysis Tools
