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| Nomenclature |
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Symbol:
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Aqp3tm1Ask
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Name:
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aquaporin 3;
targeted mutation 1, Alan S Verkman
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MGI ID: |
MGI:2150021 |
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Synonyms: |
AQP3- |
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Gene:
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Aqp3
Location:
Chr4:41092722-41098183 bp, - strand
Genetic Position: Chr4,
20.94 cM, cytoband B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61675
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Parent Cell Line:
| CB1-4 (ES Cell) |
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Strain of Origin:
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C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.3kb neomycin resistance cassette replaced parts of exons 2 and 3 of the gene. Northern blots of kidneys from homozygous mutant mice had no detectable Aqp3 transcript. Immunofluorescence analysis of fixed frozen kidney sections from homozygous mutant mice had no detectable Aqp3 protein. (J:61675)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aqp3 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:61675
Ma T et al.,
"Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels."
Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4386-91
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All: |
23 reference(s)
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Analysis Tools
