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| Nomenclature |
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Symbol:
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Irs4tm1Lhd
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Name:
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insulin receptor substrate 4;
targeted mutation 1, Gustav E Lienhard
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MGI ID: |
MGI:2149726 |
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Synonyms: |
Irs4-, IRS-4 null |
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Gene:
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Irs4
Location:
ChrX:141710998-141725263 bp, - strand
Genetic Position: ChrX,
62.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59964
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the entire coding sequence of the gene except for 457 bp at the 3' end. Reverse transcription-PCR detected no mRNA expression in brain, skeletal muscle, kidney, or liver of homozygous mutant mice. (J:59964)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:59964
Fantin VR et al.,
"Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis."
Am J Physiol Endocrinol Metab 2000 Jan;278(1):E127-33
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All: |
3 reference(s)
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Analysis Tools
