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| Nomenclature |
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Symbol:
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Hes1tm1Fgu
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Name:
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hairy and enhancer of split 1 (Drosophila);
targeted mutation 1, Francois Guillemot
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MGI ID: |
MGI:2149672 |
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Synonyms: |
Hes1- |
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Gene:
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Hes1
Location:
Chr16:30064384-30067796 bp, + strand
Genetic Position: Chr16,
21.09 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30431
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced the first three exons including sequences encoding the bHLH region of HES1. Northern blot analysis did not detect transcript in E9.5 homozygous mutant embryos. (J:30431)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hes1 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:30431
Ishibashi M et al.,
"Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects."
Genes Dev 1995 Dec 15;9(24):3136-48
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All: |
54 reference(s)
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Analysis Tools
