|
|
| Nomenclature |
|
Symbol:
|
Insrtm1Jja
|
|
Name:
|
insulin receptor;
targeted mutation 1, Jacques Jami
|
|
MGI ID: |
MGI:2149629 |
|
Synonyms: |
Insr-, IR- |
|
Gene:
|
Insr
Location:
Chr8:3150922-3279617 bp, - strand
Genetic Position: Chr8,
1.82 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:32538
|
|
Parent Cell Line:
| D3 (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin resistance cassette replaced 3.6 kb of sequence, including exon 2. Western blot analysis did not detect the protein in liver extracts from homozygous mutant mice. (J:32538)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Insr Mutation:
|
31 strains or lines available |
|
| References |
|
Original: |
J:32538
Joshi RL et al.,
"Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality."
EMBO J 1996 Apr 1;15(7):1542-7
|
|
All: |
4 reference(s)
|
|
Analysis Tools
