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| Nomenclature |
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Symbol:
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Pik3r1tm1Dfr
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Name:
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phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);
targeted mutation 1, David A Fruman
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MGI ID: |
MGI:2149438 |
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Synonyms: |
p85alpha-, p85a-p55a-p50a- |
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Gene:
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Pik3r1
Location:
Chr13:101680761-101768217 bp, - strand
Genetic Position: Chr13,
53.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52229
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced the last five exons (11 - 15) of the gene, which are common to all known splice variants. (J:52229)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:52229
Fruman DA et al.,
"Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha."
Science 1999 Jan 15;283(5400):393-7
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All: |
17 reference(s)
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Analysis Tools
