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| Nomenclature |
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Symbol:
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Pik3r1tm1Tka
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Name:
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phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);
targeted mutation 1, Takashi Kadowaki
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MGI ID: |
MGI:2149414 |
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Synonyms: |
p85alpha-, PI3K p85alpha-, Pi3kr1- |
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Gene:
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Pik3r1
Location:
Chr13:101680761-101768217 bp, - strand
Genetic Position: Chr13,
53.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52576
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced the first exon, exon 1A, of the gene. Functional analysis showed that deletion of this exon, which contains the initiation codon, abolished expression of the p85a variant, while not disrupting expression of the p50a or p55a splicing variants. (J:52576)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:52576
Terauchi Y et al.,
"Increased insulin sensitivity and hypoglycaemia in mice lacking the P85 alpha subunit of phosphoinositide 3- kinase."
Nat Genet 1999 FEB;21(2):230-235
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All: |
40 reference(s)
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Analysis Tools
