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| Nomenclature |
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Symbol:
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Tnftm1Gkl
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Name:
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tumor necrosis factor;
targeted mutation 1, George Kollias
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MGI ID: |
MGI:2149024 |
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Synonyms: |
TNF-, Tnf0, Tnfa-, Tnf-alpha-, TNFalpha-, TNFalpha KO, TNFKO |
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Gene:
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Tnf
Location:
Chr17:35199381-35202007 bp, - strand
Genetic Position: Chr17,
18.59 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47673
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of 40 bp of the 5' UTR, all the coding region, including the ATG translation initiation codon, of the first exon and part of the first intron with MC1neopA cassette. Northern blot analysis of LPS stimulated macrophages confirmed disruption of Tnf mRNA expression. (J:47673)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease when compound heterozygote with Tnftm2Gkl (J:54056).
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| References |
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Original: |
J:47673
Pasparakis M et al.,
"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response [see comments]"
J Exp Med 1996 Oct 1;184(4):1397-411
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All: |
257 reference(s)
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Analysis Tools
