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| Nomenclature |
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Symbol:
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Utrntm1Jrs
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Name:
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utrophin;
targeted mutation 1, Joshua R Sanes
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MGI ID: |
MGI:2148539 |
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Synonyms: |
uko, utrn- |
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Gene:
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Utrn
Location:
Chr10:12382188-12861735 bp, - strand
Genetic Position: Chr10,
3.77 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39218
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 2.7 kb of sequence including 52 bp of the exon that encodes the beginning of the C-terminal cysteine rich region. RT-PCR analysis demonstrated that a mutant transcript carrying the deletion was made in homozygous and heterozygous mice. Western blot analysis on extracts of muscle or lung tissue derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:39218)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39218
Grady RM et al.,
"Subtle neuromuscular defects in utrophin-deficient mice."
J Cell Biol 1997 Feb 24;136(4):871-82
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All: |
29 reference(s)
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Analysis Tools
