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| Nomenclature |
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Symbol:
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DmdGt(ROSABetageo)1Mpd
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Name:
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dystrophin, muscular dystrophy;
gene trap 1, Karin Wertz
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MGI ID: |
MGI:2148259 |
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Synonyms: |
Dmdmdx-betageo, mdx-betageo |
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Gene:
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Dmd
Location:
ChrX:82948870-85206141 bp, + strand
Genetic Position: ChrX,
38.38 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47968
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Gene trapped |
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Mutation: | |
Insertion of gene trap vector |
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Mutation details: Insertion of a gene trap vector resulted in aberrant splicing from exon 63 to the inserted Beta-geo gene. RT-PCR analysis demonstrated that the mRNA was mutated in this allele, although a very low level of wild-type transcript was detected in brain. Full length wild-type protein could not be detected by Western blotting in tissue extracts derived from hemizygous males. (J:47968)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:47968
Wertz K et al.,
"Dmd(mdx-beta geo): a new allele for the mouse dystrophin gene."
Dev Dyn 1998 Jun;212(2):229-41
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All: |
2 reference(s)
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Analysis Tools
