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| Nomenclature |
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Symbol:
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Mapttm1Noh
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Name:
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microtubule-associated protein tau;
targeted mutation 1, Nobutaka Hirokawa
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MGI ID: |
MGI:2138030 |
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Synonyms: |
tau- |
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Gene:
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Mapt
Location:
Chr11:104231390-104332090 bp, + strand
Genetic Position: Chr11,
67.79 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:19030
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A PGK-neomycin cassette was inserted into exon 1 of the gene. Mapt protein was not detected by Western blot using anti-Mapt antibodies in crude extracts from cerebrum and cerebellum or the dorsal root ganglia of homozygous mutant mice. (J:19030)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:19030
Harada A et al.,
"Altered microtubule organization in small-calibre axons of mice lacking tau protein."
Nature 1994 Jun 9;369(6480):488-91
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All: |
3 reference(s)
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Analysis Tools
