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| Nomenclature |
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Symbol:
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Ptger4tm1Bhk
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Name:
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prostaglandin E receptor 4 (subtype EP4);
targeted mutation 1, Beverly H Koller
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MGI ID: |
MGI:2137850 |
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Synonyms: |
EP4- |
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Gene:
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Ptger4
Location:
Chr15:5206661-5244187 bp, - strand
Genetic Position: Chr15,
1.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44108
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 and 2, which encode the initiation codon and regions of the gene encoding six of the seven transmembrane-spanning domains and putative extracellular loops, were replaced by a neomycin resistance gene. Northern blot analysis of RNA from thymus and spleen of homozygous mutant neonates using cDNA probes specific for this gene verified the loss of expression. (J:44108)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptger4 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:44108
Nguyen M et al.,
"The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth."
Nature 1997 Nov 6;390(6655):78-81
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All: |
15 reference(s)
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Analysis Tools
