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| Nomenclature |
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Symbol:
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Mmetm1Cge
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Name:
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membrane metallo endopeptidase;
targeted mutation 1, Craig Gerard
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MGI ID: |
MGI:2137696 |
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Synonyms: |
NEP- |
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Gene:
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Mme
Location:
Chr3:63295872-63382231 bp, + strand
Genetic Position: Chr3,
29.97 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70516
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced 0.6kb of sequence containing exon 13 and part of intron 13. Northern blot analysis using a cDNA probe for the active site region, exons 14 - 20, did not detect message in renal tissue from homozygous mutant pups. (J:70516)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mme Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:70516
Lu B et al.,
"Neutral endopeptidase modulation of septic shock."
J Exp Med 1995 Jun 1;181(6):2271-5
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All: |
20 reference(s)
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Analysis Tools
