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| Nomenclature |
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Symbol:
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Mecp2tm1Bird
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Name:
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methyl CpG binding protein 2;
targeted mutation 1, Adrian Bird
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MGI ID: |
MGI:2137555 |
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Synonyms: |
Mecp2lox |
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Gene:
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Mecp2
Location:
ChrX:74026592-74085690 bp, - strand
Genetic Position: ChrX,
37.63 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67910
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a neomycin resistance cassette into the gene introduced loxP sites that flank exons 3 and 4, and added an intron and polyadenylation signal from the human beta globin gene. From the mutated allele, Northern blot analysis detected the wild type mature transcript and also a transcript in which the beta globin intron was unspliced. (J:67910)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67910
Guy J et al.,
"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome."
Nat Genet 2001 Mar;27(3):322-6
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All: |
12 reference(s)
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Analysis Tools
