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| Nomenclature |
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Symbol:
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Nr1h4tm1Gonz
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Name:
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nuclear receptor subfamily 1, group H, member 4;
targeted mutation 1, Frank Gonzalez
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MGI ID: |
MGI:2137330 |
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Synonyms: |
FXR-, FXRalpha-, FXR/BAR -, Fxrtm1Gonz |
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Gene:
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Nr1h4
Location:
Chr10:89454234-89533585 bp, - strand
Genetic Position: Chr10,
44.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64792
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Mice with a targeted deletion of the last exon encoding the ligand binding domain and all of the 3' untranslated region were produced as follows: A loxP site was inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette was inserted 3' to the last exon. After production of chimeric founder mice, F1 mice were mated to Tg(EIIa-Cre)1Lmgd mice to produce offspring that carried a recombined deletion of the last exon and neomycin cassette. No Nr1h4 protein product is detected in liver tissue from these null mice although an aberrant transcript appears to be generated. (J:64792)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The ES cell line was not specified, but was purchased from Genome Systems (St. Louis, MO). (Note added 7/26/01: Genome Systems was bought by Incyte.)
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| References |
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Original: |
J:64792
Sinal CJ et al.,
"Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis"
Cell 2000 Sep 15;102(6):731-44
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All: |
77 reference(s)
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Analysis Tools
