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| Nomenclature |
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Symbol:
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En1tm1Gld
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Name:
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engrailed 1;
targeted mutation 1, Martyn Goulding
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MGI ID: |
MGI:2137030 |
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Synonyms: |
En1-, En1taulacZ, En1/tauLacZ, En1tau-LacZ, En1tlZ |
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Gene:
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En1
Location:
Chr1:120602418-120609296 bp, + strand
Genetic Position: Chr1,
52.74 cM, cytoband C2-qter
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52637
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A tau-lacZ reporter gene cassette was inserted into the first exon, replacing sequences encoding the endogenous methionine initiation codon and the first 72 amino acids. Heterozygous mice expressed tau-beta-galactosidase that was indistinguishable from the endogenous expression pattern of En1. (J:52637)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any En1 Mutation:
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8 strains or lines available |
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Notes |
Mice heterozygous for En1tm1Gld and homozygous for En2tm1Alj display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:115270)
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| References |
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Original: |
J:52637
Saueressig H et al.,
"Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons."
Development 1999 Oct;126(19):4201-12
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All: |
9 reference(s)
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Analysis Tools
