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| Nomenclature |
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Symbol:
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Rettm2.1Cos
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Name:
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ret proto-oncogene;
targeted mutation 2.1, Frank Costantini
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MGI ID: |
MGI:2136896 |
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Synonyms: |
retMEN2B |
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Gene:
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Ret
Location:
Chr6:118151748-118197744 bp, - strand
Genetic Position: Chr6,
55.86 cM, cytoband E3-F1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:60659
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A T to C transition in codon 919, the equivalent codon to human 918, resulted in a protein which encoded threonine instead of methionine at this position. Silent mutations in codons 920 and 921 abolished a MunI endonuclease site. An adjacent loxP flanked neomycin cassette was removed by crossing mice carrying Rettm2Cos to mice expressing Cre under the control of a Beta-actin promoter. (J:60659)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:60659
Smith-Hicks CL et al.,
"C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B."
EMBO J 2000 Feb 15;19(4):612-22
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All: |
7 reference(s)
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Analysis Tools
