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| Nomenclature |
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Symbol:
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Rettm1Cos
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Name:
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ret proto-oncogene;
targeted mutation 1, Frank Costantini
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MGI ID: |
MGI:2136894 |
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Synonyms: |
c-ret-, Ret-, ret-k- |
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Gene:
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Ret
Location:
Chr6:118151748-118197744 bp, - strand
Genetic Position: Chr6,
55.86 cM, cytoband E3-F1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:23852
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 0.8 kb of sequence, including the codon for an invariant lysine required for kinase activity. Northern blot analysis did not detect normal transcripts in brains of homozygous mice, but did detect several transcripts with sizes consistent with predicted products of the mutant allele. (J:23852)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:23852
Schuchardt A et al.,
"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret [see comments]"
Nature 1994 Jan 27;367(6461):380-3
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All: |
38 reference(s)
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Analysis Tools
