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| Nomenclature |
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Symbol:
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Apptm1Dbo
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Name:
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amyloid beta (A4) precursor protein;
targeted mutation 1, David R Borchelt
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MGI ID: |
MGI:2136847 |
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Synonyms: |
App- |
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Gene:
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App
Location:
Chr16:84954440-85173707 bp, - strand
Genetic Position: Chr16,
46.92 cM, cytoband C3-qter
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25512
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a 3.8 kb sequence including the promoter region and first exon. Northern blot analysis did not detect mRNA in brain or kidney of homozygous mutant mice. (J:25512)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:25512
Zheng H et al.,
"beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity."
Cell 1995 May 19;81(4):525-31
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All: |
52 reference(s)
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Analysis Tools
