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| Nomenclature |
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Symbol:
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Vhltm1.1Jae
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Name:
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von Hippel-Lindau tumor suppressor;
targeted mutation 1.1, Rudolf Jaenisch
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MGI ID: |
MGI:2136646 |
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Synonyms: |
1-lox allele, VHL1, Vhld, Vhl
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Gene:
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Vhl
Location:
Chr6:113623959-113631633 bp, + strand
Genetic Position: Chr6,
52.81 cM
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Vascular tumors in livers and histological comparison of vascular lesions in Vhlh/+ and Vhlhtm1Jae/Vhlhtm1Jae Tg(Alb-cre)21Mgn/0 mutant mice.
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67505
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6kb upstream of exon 1. A third loxP site was inserted into intron 1. ES cells with this mutation were transiently transfected with a vector driving expression of Cre recombinase. ES cells containing only one loxP site, in which the promoter and exon 1 were deleted, were selected. These cells were injected into blastocyts to generate a the allele designated Vhltm1.1Jae. (J:67505)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Vhl Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:67505
Haase VH et al.,
"Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor."
Proc Natl Acad Sci U S A 2001 Feb 13;98(4):1583-8
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All: |
4 reference(s)
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Analysis Tools
