|
|
| Nomenclature |
|
Symbol:
|
Irs1tm1Tka
|
|
Name:
|
insulin receptor substrate 1;
targeted mutation 1, Takashi Kadowaki
|
|
MGI ID: |
MGI:2136643 |
|
Synonyms: |
IRS-1- |
|
Gene:
|
Irs1
Location:
Chr1:82233101-82291416 bp, - strand
Genetic Position: Chr1,
42.0 cM, cytoband C5
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:21373
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A PGK-neomycin cassette disrupted the first exon of the gene, preventing the production of stable mRNA transcripts. No transcript was detected in hepatic tissues of homozygous null mice by Northern blot analysis. Western blots of liver homogenates showed no detectable protein. (J:21373)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Irs1 Mutation:
|
3 strains or lines available |
|
| References |
|
Original: |
J:21373
Tamemoto H et al.,
"Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 [see comments]"
Nature 1994 Nov 10;372(6502):182-6
|
|
All: |
21 reference(s)
|
|
Analysis Tools
