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| Nomenclature |
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Symbol:
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Ren1tm1Afu
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Name:
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renin 1 structural;
targeted mutation 1, Akiyoshi Fukamizu
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MGI ID: |
MGI:2136642 |
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Synonyms: |
renin- |
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Gene:
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Ren1
Location:
Chr1:133350510-133360325 bp, + strand
Genetic Position: Chr1,
57.91 cM
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Ren1tm1Afu/Ren1tm1Afu mice exhibit kidney abnormalities
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59299
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ-neomycin reistance cassette replaced the first three exons. Northern blot analysis of kidney did not detect RNA in homozygous mutant mice. (J:59299)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:59299
Yanai K et al.,
"Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice."
J Biol Chem 2000 Jan 7;275(1):5-8
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All: |
2 reference(s)
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Analysis Tools
