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| Nomenclature |
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Symbol:
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Vegfatm2Pec
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Name:
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vascular endothelial growth factor A;
targeted mutation 2, Peter Carmeliet
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MGI ID: |
MGI:2136623 |
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Synonyms: |
Vegfdelta |
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Gene:
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Vegfa
Location:
Chr17:46016993-46032369 bp, - strand
Genetic Position: Chr17,
22.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69797
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Deletion of the hypoxia-response element (HRE) in the promoter of the gene. An adajcent neomycin cassette was removed prior to blastocyst injection via Cre-mediated recombination in ES cells, resulting in the final allele. (J:69797)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Vegfa Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:69797
Oosthuyse B et al.,
"Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration."
Nat Genet 2001 Jun;28(2):131-8
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All: |
7 reference(s)
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Analysis Tools
