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| Nomenclature |
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Symbol:
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Irs1tm1Jos
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Name:
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insulin receptor substrate 1;
targeted mutation 1, Joslin Diabetes Center
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MGI ID: |
MGI:2136455 |
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Synonyms: |
Irs1-, IRS-1-, IRS-1 KO |
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Gene:
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Irs1
Location:
Chr1:82233101-82291416 bp, - strand
Genetic Position: Chr1,
42.0 cM, cytoband C5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:21374
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced bases -77 to + 179 of the gene, deleting the start codon and producing a shift in the reading frame. Western blots of liver and muscle extracts showed no detectable protein. (J:21374, J:169458)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irs1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:21374
Araki E et al.,
"Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene [see comments]"
Nature 1994 Nov 10;372(6502):186-90
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All: |
34 reference(s)
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Analysis Tools
