|
|
| Nomenclature |
|
Symbol:
|
Rxratm2Ipc
|
|
Name:
|
retinoid X receptor alpha;
targeted mutation 2, Pierre Chambon
|
|
MGI ID: |
MGI:2136274 |
|
Synonyms: |
RXR-alpha- |
|
Gene:
|
Rxra
Location:
Chr2:27676440-27762957 bp, + strand
Genetic Position: Chr2,
19.38 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:20550
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Replacement of exon 4 with a PGK-Neo cassette. Western analysis using a polyclonal antibody directed against the N-terminus failed to detect the protein in homozygous mutant animals. (J:20550)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Rxra Mutation:
|
6 strains or lines available |
|
|
Notes |
Two ES cell lines were used: D3 and H1
|
| References |
|
Original: |
J:20550
Kastner P et al.,
"Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis."
Cell 1994 Sep 23;78(6):987-1003
|
|
All: |
16 reference(s)
|
|
Analysis Tools
