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| Nomenclature |
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Symbol:
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Pitx2tm2Jfm
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Name:
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paired-like homeodomain transcription factor 2;
targeted mutation 2, James F Martin
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MGI ID: |
MGI:2136269 |
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Synonyms: |
delta abhypoc |
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Gene:
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Pitx2
Location:
Chr3:129199878-129219591 bp, + strand
Genetic Position: Chr3,
57.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69854
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: An IRES-lacZ cassette followed by a loxP-flanked neomycin resistance cassette replaced a genomic fragment containing the coding region of exon 2 and all of exon 3. This allele encodes the heart- and lung-specific c isoform in the absence of the a and b isoforms. The presence of the retained neomycin resistance cassette results in a hypomorphic allele. (J:69854)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pitx2 Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:69854
Liu C et al.,
"Regulation of left-right asymmetry by thresholds of Pitx2c activity."
Development 2001 Jun;128(11):2039-48
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All: |
3 reference(s)
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Analysis Tools
