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| Nomenclature |
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Symbol:
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Klc1tm1Gsn
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Name:
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kinesin light chain 1;
targeted mutation 1, Lawrence S B Goldstein
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MGI ID: |
MGI:2136259 |
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Gene:
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Klc1
Location:
Chr12:111758849-111807844 bp, + strand
Genetic Position: Chr12,
61.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57877
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An IRES Beta-geo cassette replaced the exon that encodes the entire first TPR domain and part of the second TPR domain. Western analysis of crude cytoplasmic brain extracts of homozygous mutant mice detected dramatically reduced levels of full length KLC1, as well as very small amounts of truncated KLC1. Immunoprecipitation studies did not detect either form of KLC1 in KIF5A or KIF5B coprecipitates of brain extracts of homozygous mutant mice. Immunofluorescence studies of sensory and motor neuron cell bodies in dorsal root ganglion and spinal cord of homozygous mutant mice detected very faint KCL1 staining. (J:57877)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57877
Rahman A et al.,
"Defective kinesin heavy chain behavior in mouse kinesin light chain mutants."
J Cell Biol 1999 Sep 20;146(6):1277-88
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All: |
6 reference(s)
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Analysis Tools
