|
|
| Nomenclature |
|
Symbol:
|
Fgfr3tm1Cxd
|
|
Name:
|
fibroblast growth factor receptor 3;
targeted mutation 1, Chu-Xia Deng
|
|
MGI ID: |
MGI:2135666 |
|
Synonyms: |
pFgfr3-TD |
|
Gene:
|
Fgfr3
Location:
Chr5:33721724-33737067 bp, + strand
Genetic Position: Chr5,
17.83 cM, cytoband B
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:52438
|
|
Parent Cell Line:
| TC1/TC-1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Knock-in construct in which a portion of a cDNA corresponding to exons 5-19 followed by a polyadenylation signal was inserted into the endogenous locus. This allele carried a point mutation in codon 644 that altered the corresponding amino acid from lysine to glutamine. A loxP flanked neomycin cassette also inserted downstream of the inseted cDNA was removed via Cre mediated recombination in the final allele. (J:52438)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Fgfr3 Mutation:
|
7 strains or lines available |
|
| References |
|
Original: |
J:52438
Li C et al.,
"A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors."
Hum Mol Genet 1999 Jan;8(1):35-44
|
|
All: |
1 reference(s)
|
|
Analysis Tools
