|
|
| Nomenclature |
|
Symbol:
|
Fgfr3tm2Wei
|
|
Name:
|
fibroblast growth factor receptor 3;
targeted mutation 2, Weizmann Institute of Science
|
|
MGI ID: |
MGI:2135636 |
|
Synonyms: |
Fgfr3G374R, FGFR3G374Rneo- |
|
Gene:
|
Fgfr3
Location:
Chr5:33721724-33737067 bp, + strand
Genetic Position: Chr5,
17.83 cM, cytoband B
|
|
Anatomical defects of the Fgfr3tm2Wei/Fgfr3+ mouse
Show the 2 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:54829
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Single point mutation |
| |
|
Mutation details: Introduction of a G to A point mutation in codon 374 (orthologous to human codon 380) that altered the corresponding amino acid from a glycine to an arginine. A loxP flanked neomycin cassette inserted into intron 4 was removed by cre-mediated recombination. Northern blot analysis revealed that a normal molecular weight mRNA was made in homozygous mutants. (J:54829)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Fgfr3 Mutation:
|
7 strains or lines available |
|
| References |
|
Original: |
J:54829
Wang Y et al.,
"A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3."
Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4455-60
|
|
All: |
3 reference(s)
|
|
Analysis Tools
