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| Nomenclature |
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Symbol:
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Abca1tm1Wpfl
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 1;
targeted mutation 1, Wai-Ping Fung-Leung
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MGI ID: |
MGI:1935193 |
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Synonyms: |
ABCA1- |
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Gene:
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Abca1
Location:
Chr4:53030787-53159895 bp, - strand
Genetic Position: Chr4,
28.57 cM, cytoband A5-B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64390
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.9 kb genomic fragment containing exons 19, 20 and part of 21 was deleted and replaced with a neomycin selection cassette. Northern blot and RT-PCR analysis indicated that a truncated transcript is produced from this allele, but any protein produced from this transcript is predicted to be nonfunctional. (J:64390)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abca1 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:64390
Christiansen-Weber TA et al.,
"Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency."
Am J Pathol 2000 Sep;157(3):1017-29
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All: |
11 reference(s)
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Analysis Tools
