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| Nomenclature |
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Symbol:
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Abca1tm1Jdm
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 1;
targeted mutation 1, John D McNeish
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MGI ID: |
MGI:1935192 |
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Synonyms: |
Abc1-, Abca1-, Abca1- |
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Gene:
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Abca1
Location:
Chr4:53030787-53159895 bp, - strand
Genetic Position: Chr4,
28.57 cM, cytoband A5-B3
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Pulmonary lesions in Abca1tm1Jdm/Abca1tm1Jdm mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61679
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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DBA/1LacJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 5.7 kb genomic fragment containing exons 17-22 was deleted and replaced with a neomycin selection cassette. These sequences correspond to amino acids 788 to 1093 of the encoded protein. RT-PCR analysis on RNA derived from liver demonstrated that no detectable transcript was produced from this allele in homozygous mice. (J:61679)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
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| References |
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Original: |
J:61679
McNeish J et al.,
"High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1."
Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4245-50
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All: |
64 reference(s)
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Analysis Tools
