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| Nomenclature |
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Symbol:
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Mgptm1Kry
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Name:
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matrix Gla protein;
targeted mutation 1, Gerard Karsenty
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MGI ID: |
MGI:1934912 |
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Synonyms: |
MGP-, mgpm1 |
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Gene:
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Mgp
Location:
Chr6:136872436-136875805 bp, - strand
Genetic Position: Chr6,
66.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38867
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a 3.4 kb fragment of the gene containing the proximal promoter, exons 1, 2, 3, and most of 4. Northern blots of RNA from lungs of homozygous mutant mice showed no detectable transcript for the targeted protein. (J:38867)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mgp Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:38867
Luo G et al.,
"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein."
Nature 1997 Mar 6;386(6620):78-81
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All: |
9 reference(s)
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Analysis Tools
