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| Nomenclature |
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Symbol:
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Dag1tm1Kcam
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Name:
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dystroglycan 1;
targeted mutation 1, Kevin P Campbell
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MGI ID: |
MGI:1934902 |
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Synonyms: |
Dag1neo2, DG- |
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Gene:
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Dag1
Location:
Chr9:108205958-108263736 bp, - strand
Genetic Position: Chr9,
59.08 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40601
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced part of exon 2, including the splice acceptor site and a large part of the coding sequence. No detectable transcript was produced from this allele in homozygous embryos (data not shown) and immunohistochemistry experiments on homozygous embryos confirmed that no detectable encoded protein was present. (J:40601)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:40601
Williamson RA et al.,
"Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice."
Hum Mol Genet 1997 Jun;6(6):831-41
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All: |
4 reference(s)
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Analysis Tools
