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| Nomenclature |
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Symbol:
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Col4a3tm1Jhm
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Name:
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collagen, type IV, alpha 3;
targeted mutation 1, Jeffrey H Miner
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MGI ID: |
MGI:1934893 |
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Synonyms: |
COL4A3- |
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Gene:
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Col4a3
Location:
Chr1:82586921-82722059 bp, + strand
Genetic Position: Chr1,
42.32 cM
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Kidney abnormalities in Col4a3tm1Jhm/Col4a3tm1Jhm mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:37017
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of the first three coding exons with a neomycin cassette. No protein was detectable by immunohistochemical analysis on homozygous mice. (J:37017)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Col4a3 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:37017
Miner JH et al.,
"Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome."
J Cell Biol 1996 Dec;135(5):1403-13
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All: |
9 reference(s)
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Analysis Tools
