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| Nomenclature |
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Symbol:
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Hspg2tm1Nid
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Name:
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perlecan (heparan sulfate proteoglycan 2);
targeted mutation 1, National Institute of Dental and Craniofacial Research
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MGI ID: |
MGI:1934891 |
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Synonyms: |
Hspg2- |
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Gene:
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Hspg2
Location:
Chr4:137468769-137570630 bp, + strand
Genetic Position: Chr4,
69.93 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67299
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 7 of the gene, which encodes the N-terminus of the LDL-receptor-like domain of the protein. Northern blots of fibroblast RNA from homozygous mutant mice showed no detectable transcript for the targeted gene. (J:67299)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67299
Arikawa-Hirasawa E et al.,
"Perlecan is essential for cartilage and cephalic development."
Nat Genet 1999 Nov;23(3):354-8
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All: |
6 reference(s)
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Analysis Tools
