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| Nomenclature |
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Symbol:
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Prnptm1Rcm
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Name:
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prion protein;
targeted mutation 1, Richard C Moore
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MGI ID: |
MGI:1934273 |
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Synonyms: |
Prnpa[108F189V], PrP gtB |
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Gene:
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Prnp
Location:
Chr2:131909928-131938429 bp, + strand
Genetic Position: Chr2,
64.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45908
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: The 129P2/OlaHsd strain normally carries the PrP A allotype, with leucine and threonine at residues 108 and 189. In this allele, the sequences encoding these amino acids were altered to instead encode phenylalanine and valine. These changes alter the allotype to one identical to PrP B. (J:29021)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prnp Mutation:
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71 strains or lines available |
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| References |
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Original: |
J:45908
Moore RC et al.,
"Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent [see comments]"
Nat Genet 1998 Feb;18(2):118-25
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All: |
4 reference(s)
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Analysis Tools
