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| Nomenclature |
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Symbol:
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Prnptm1Miy
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Name:
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prion protein;
targeted mutation 1, Tsutomu Miyamoto
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MGI ID: |
MGI:1934272 |
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Synonyms: |
Nagasaki, Ngsk Prnp0, Prnp-, PrP |
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Gene:
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Prnp
Location:
Chr2:131909928-131938429 bp, + strand
Genetic Position: Chr2,
64.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69186
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding sequence of the gene was replaced with a neomycin cassette. No mRNA was detected in the brains of homozyogous mutant mice by either Northern blotting or by in situ hybridization. (J:69186)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prnp Mutation:
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71 strains or lines available |
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| References |
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Original: |
J:69186
Sakaguchi S et al.,
"Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent."
J Virol 1995 Dec;69(12):7586-92
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All: |
19 reference(s)
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Analysis Tools
